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New project for profiling coronavirus-infected cells funded by SciLifeLab and KAW!

6 May, 2020

Our recent grant application Multi-level profiling of Coronavirus-infected cells by combining Viral Entry Assays, Cell Painting, and DrugSEQ was awarded 500 KSEK by SciLifeLab and Knut och Alice Wallenbergs Stiftelse in a joint effort with others to tackle COVID-19.

Our team thereby joins the research area SciLifeLab Drug discovery and repurposing of drugs.

Our group leads a project to profile corona-infected cells using our Cell Painting methodology, and combine cell morphology data with RNAseq data from the Nelander lab using their DrugSEQ methodology. The experiments on coronavirus will be made in the Helleday lab at Karolinska Institutet. The drug compounds we will expose the cells to come from Chemical Biology Consortium Sweden (CBCS). We are very much looking forward to this new project and collaboration!

Virtual Screening towards COVID-19

Together with company Prosilico, our team is also contributing with predictive ADME models and expertise to an Open Source virtual screening effort based on the structure of the SARS-CoV-2 main protease as solved by Diamond. All code and predictions are available openly on https://github.com/tdudgeon/jupyter_mpro.